Targeting cystatin F activation enhances NK cell cytotoxicity in glioblastoma models
These results indicate that cystatin F mediates NK cell suppression in GBM. Targeting its activation enhances NK cell cytotoxicity, offering a potential strategy to improve NK-based immunotherapy for glioblastoma.
Authors
- Emanuela Senjor (ORCID: https://orcid.org/0000-0002-1040-5365)
- Anamarija Habič (ORCID: https://orcid.org/0000-0002-6373-7603)
- Stanislav Gobec (ORCID: https://orcid.org/0000-0002-9678-3083)
- Andrej Porčnik
- Borut Prestor (ORCID: https://orcid.org/0000-0002-5464-5424)
- Miha Jerala (ORCID: https://orcid.org/0000-0002-2391-8776)
- Matic Bošnjak (ORCID: https://orcid.org/0000-0002-5536-7518)
- Janko Kos (ORCID: https://orcid.org/0000-0002-4228-3518)
- Barbara Breznik (ORCID: https://orcid.org/0000-0003-0247-5811)
- Matic Proj
- Ana Mitrović (ORCID: https://orcid.org/0000-0002-6996-4831)
- Urban Švajger (ORCID: https://orcid.org/0000-0002-1908-4254)
- Milica Perišić Nanut (ORCID: https://orcid.org/0000-0003-2314-2733)
Institutions
- University of Ljubljana (SI)
- Ljubljana University Medical Centre (SI)
- Jožef Stefan Institute (SI)
- Blood Transfusion Centre of Slovenia (SI)
- Jožef Stefan International Postgraduate School (SI)
- National Institute of Biology (SI)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1708281
- Citations
- 1
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- European Commission