HDAC7 knockout mitigates astrocyte reactivity and neuroinflammation via the IRF3/cGAS/STING signaling pathway
Our results delineate a novel HDAC7/IRF3/cGAS/STING signaling axis that governs astrocyte reactivity. This discovery provides a crucial cellular neurophysiological mechanism by which astrocytes integrate inflammatory signals and subsequently modulate the central nervous system microenvironment. Targeting HDAC7, therefore, represents a therapeutic strategy to mitigate neuroinflammation by specifically correcting this aberrant cell-physiological state of astrocytes, ultimately preserving neural circuit function.
Authors
- Chaokun Li (ORCID: https://orcid.org/0000-0001-9037-488X)
- Rui-zhu Yue
- Linlin Shan (ORCID: https://orcid.org/0000-0003-2068-8060)
- Xing Guo (ORCID: https://orcid.org/0000-0001-5585-2970)
- Wenqiang Li (ORCID: https://orcid.org/0009-0002-2593-0194)
Institutions
- Henan Psychiatric Hospital (CN)
- China Agricultural University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fncel.2025.1683595
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Henan Province