Prediction of intracranial response to PD-1/PD-L1 inhibitors therapy in brain metastases originating from non-small cell lung cancer using habitat imaging and peritumoral radiomics: a multicenter study
The validated habitat-peritumoral radiomics framework, optimized at a 1-mm peritumoral extent, demonstrates robust predictive accuracy for intracranial immunotherapy response in NSCLC-BM patients and offers significant clinical utility.
Authors
- Wei Song (ORCID: https://orcid.org/0000-0001-6696-1208)
- Ning Luo (ORCID: https://orcid.org/0000-0001-5123-7102)
- Jian Zheng (ORCID: https://orcid.org/0000-0001-9564-7357)
- Yuan Yuan (ORCID: https://orcid.org/0000-0002-7394-9036)
- Qi Wang (ORCID: https://orcid.org/0000-0002-5287-6050)
- Wenwen Liu (ORCID: https://orcid.org/0009-0000-1948-4840)
- Jing Yu (ORCID: https://orcid.org/0000-0002-8694-8948)
- Xin Qi (ORCID: https://orcid.org/0000-0001-9038-4287)
- Li‐Ting Liu (ORCID: https://orcid.org/0000-0002-7641-4774)
- Hongxu Liu (ORCID: https://orcid.org/0000-0003-1828-1085)
- Chao Yang (ORCID: https://orcid.org/0000-0003-2457-9988)
- Chun-Hui Yang (ORCID: https://orcid.org/0000-0002-0532-1060)
- Yiyang Sun (ORCID: https://orcid.org/0009-0003-6353-4624)
- Tianrui He
- Min Ding
- Dailun Hou
Institutions
- Shanghai Medical College of Fudan University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Beijing Chest Hospital (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- Liaoning Cancer Hospital & Institute (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fonc.2025.1657290
- Primary Topic
- Radiomics and Machine Learning in Medical Imaging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Dalian Medical University
- Dalian Institute of Chemical Physics