Temporal dynamics of cisplatin-induced endothelial senescence and its association with cognitive impairment: insights into the medial prefrontal cortex
This study delineates a temporal cascade wherein cisplatin induces early mPFC endothelial senescence with delayed BBB dysfunction and neuroinflammation, driving chronic working memory impairment, thus indicating endothelial senescence as early-stage potential target for mitigating CRCI, especially in mPFC-related working memory deficits.
Authors
- Jinlong Sun (ORCID: https://orcid.org/0000-0002-5999-6047)
- Qianfa Long (ORCID: https://orcid.org/0000-0001-8848-9688)
- Yue Hei
- Shu Kong (ORCID: https://orcid.org/0000-0002-1362-5937)
- Hongmei Zhang (ORCID: https://orcid.org/0000-0002-2866-8227)
- Weiping Liu (ORCID: https://orcid.org/0000-0003-0841-0250)
Institutions
- Northwest University (CN)
- Xijing Hospital (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fonc.2025.1668372
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China