Intestinal mucosal alterations parallel central demyelination and remyelination: insights into the gut-brain axis in the cuprizone model of multiple sclerosis
Our findings reveal that cuprizone-induced intestinal dysfunctions temporally parallel central nervous system (CNS) lesion dynamics, disclosing temporal coordination of both compartments and highlighting gut-brain axis impact on both disease stages.
Authors
- Filipe Palavra (ORCID: https://orcid.org/0000-0002-2165-130X)
- Flávio Reis (ORCID: https://orcid.org/0000-0003-3401-9554)
- Manuela Pintado (ORCID: https://orcid.org/0000-0002-0760-3184)
- Filipa S. Carvalho (ORCID: https://orcid.org/0000-0002-0074-0741)
- Sofia Viana
- Patrícia Dias‐Pereira (ORCID: https://orcid.org/0000-0002-8845-794X)
- André de Castro Alves (ORCID: https://orcid.org/0000-0002-6445-1543)
- Ezequiel R. Coscueta (ORCID: https://orcid.org/0000-0003-4496-2001)
- Pedro M. Moraes‐Vieira (ORCID: https://orcid.org/0000-0002-8263-786X)
- Miguel Castelo‐Branco (ORCID: https://orcid.org/0000-0003-4364-6373)
- Vera Alves (ORCID: https://orcid.org/0000-0002-2625-1671)
- Carolina Ferreira (ORCID: https://orcid.org/0000-0002-4074-9513)
- Javier Almeida
Institutions
- Universidade do Porto (PT)
- Universidade Católica Portuguesa (PT)
- Hospitais da Universidade de Coimbra (PT)
- Polytechnic Institute of Coimbra (PT)
- Rede de Química e Tecnologia (PT)
- Instituto Português de Oncologia de Coimbra Francisco Gentil (PT)
- University of Coimbra (PT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1682183
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00