Immune-related inflammatory gene in hypertrophic scar: prognostic and molecular mechanisms via integrated machine learning-WGCNA analysis
The immune-inflammation related genes COL1A1, A2M, TIMP1, and COL1A2 were identified as novel signature genes in HTS. The nomogram established based on these genes demonstrated high clinical diagnosis value. These findings provide evidence for early diagnosis and personalized therapeutic strategies in HTS management.
Authors
- Chunfeng Zhao (ORCID: https://orcid.org/0000-0002-8737-4587)
- Xin Wang (ORCID: https://orcid.org/0000-0002-9265-7741)
- Huiling Li (ORCID: https://orcid.org/0000-0002-4195-691X)
- Yufang Liu (ORCID: https://orcid.org/0000-0001-7645-586X)
Institutions
- Weifang People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1645721
- Primary Topic
- Dermatologic Treatments and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00