A murine model of prurigo nodularis-like skin lesions induced by persistent scratching under type 2 inflammatory conditions
This optimized model faithfully recapitulates the key clinicopathological features of PN patients, providing a robust preclinical platform for investigating disease mechanisms and evaluating potential therapeutics.
Authors
- Siyi Tang
- Jiamin Yan (ORCID: https://orcid.org/0000-0002-2050-2222)
- Kaoyuan Zhang (ORCID: https://orcid.org/0000-0001-7859-4599)
- Xiahong Li (ORCID: https://orcid.org/0009-0007-7584-8806)
- Xia Dou (ORCID: https://orcid.org/0000-0001-9316-4466)
- Xiaofan Chen (ORCID: https://orcid.org/0000-0001-6639-1313)
- Jiali Wu
- Siqi Huang (ORCID: https://orcid.org/0000-0003-4964-490X)
Institutions
- City University of Hong Kong, Shenzhen Research Institute (CN)
- Peking University Shenzhen Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1648830
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Peking University