Microbial culture vs. mNGS: diagnostic variations in periprosthetic joint infection
Clinicians should optimize diagnostic strategies by tailoring microbial culture methods to the patient's clinical condition and integrating mNGS testing where appropriate. It is recommended to use tissue specimens from the same anatomical site across multiple tests while sampling from different regions when necessary. Although this approach may increase costs, it significantly enhances the accuracy of pathogen identification and facilitates more effective treatment.
Authors
- Xinyu Fang (ORCID: https://orcid.org/0000-0002-8004-5182)
- Baijian Wu (ORCID: https://orcid.org/0000-0002-5738-6595)
- Zida Huang (ORCID: https://orcid.org/0000-0002-5204-2005)
- Jiayu Li
- Yiming Lin (ORCID: https://orcid.org/0000-0002-4776-4441)
- Yufeng Guo (ORCID: https://orcid.org/0009-0008-9153-7335)
- Wenbo Li (ORCID: https://orcid.org/0000-0002-6586-6118)
- Xiaolin Li (ORCID: https://orcid.org/0000-0003-1524-051X)
- Hongyan Li (ORCID: https://orcid.org/0000-0003-3603-4045)
- Wenming Zhang (ORCID: https://orcid.org/0000-0002-8101-4089)
- Lan Lin
- Chuanqiang Huang
Institutions
- Fujian Medical University (CN)
- Zhangzhou Municipal Hospital of Fujian Province (CN)
- Ningde Normal University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fcimb.2025.1611332
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fujian Medical University