Repurposing risperidone as an anti-angiogenic agent for triple-negative breast cancer: a computational to in ovo investigation
We could prove that a structure-based drug repurposing approach is an effective strategy to produce a promising antiangiogenic repurposed drug that could also inhibit VEGFR2 in breast cancer. Although risperidone showed modest potency, its clinical availability and repurposing potential support further evaluation in preclinical and clinical settings.
Authors
- Chandan Dharmashekar
- Jordi Codony‐Servat (ORCID: https://orcid.org/0000-0001-8239-9016)
- Manchikanti Srinivas
- Bhargav Shreevatsa (ORCID: https://orcid.org/0000-0001-8799-1078)
- Sudhanva M. Srinivasa (ORCID: https://orcid.org/0000-0001-9141-6148)
- Ekaterina Silina (ORCID: https://orcid.org/0000-0002-0246-5149)
- Muzaffar Iqbal (ORCID: https://orcid.org/0000-0001-5821-5600)
- Kasim Sakran Abass (ORCID: https://orcid.org/0000-0002-5796-7170)
- Chandan Shivamallu (ORCID: https://orcid.org/0000-0002-1886-139X)
- Raghavendra G G Amachawadi (ORCID: https://orcid.org/0000-0001-9689-1124)
- Rafael Rosell (ORCID: https://orcid.org/0000-0003-0817-3400)
- Anil Kumar Belagal Motatis (ORCID: https://orcid.org/0000-0002-8799-5164)
- Victor Stupin (ORCID: https://orcid.org/0000-0002-9522-8061)
- Shobith Rangappa (ORCID: https://orcid.org/0000-0002-9800-7192)
- Shiva Prasad Kollur (ORCID: https://orcid.org/0000-0003-3914-3933)
- Anisha Jain (ORCID: https://orcid.org/0000-0003-1998-3556)
- Sotomaior Vs
- P Ashwini
- M. N. Nagendra Prasad (ORCID: https://orcid.org/0000-0002-9803-3796)
Institutions
- University of Kirkuk (IQ)
- JSS Academy of Higher Education and Research (IN)
- Sechenov University (RU)
- Kansas State University (US)
- King Saud University (SA)
- Rajiv Gandhi University of Health Sciences (IN)
- Pirogov Russian National Research Medical University (RU)
- Instituto Oncológico Dr. Rosell (ES)
- Hospital Universitario Dexeus (ES)
- USP Institut Universitari Dexeus (ES)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- JSS Science and Technology University (IN)
- Institute for Molecular Medicine (US)
- Amrita Vishwa Vidyapeetham (IN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fonc.2025.1645905
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amrita Vishwa Vidyapeetham University
- JSS Academy of Higher Education and Research
- Department of Biotechnology, Ministry of Science and Technology, India
- King Saud University