The prognostic significance of incomplete hematological recovery in pediatric patients with low/intermediate risk AML and negative MRD after induction 1
In MRD-negative pediatric AML, incomplete hematologic recovery did not significantly predict inferior survival, though trends suggest potential prognostic value-particularly in low-risk patients. CRi may reflect treatment-related toxicity or infectious complications rather than residual disease. These findings support a more nuanced interpretation of remission depth and highlight the need for larger, multi-institutional studies incorporating molecular risk refinement and clinical context.
Authors
- Leslie Lehmann (ORCID: https://orcid.org/0000-0001-5558-4830)
- Hanafy Hafez (ORCID: https://orcid.org/0000-0003-1093-933X)
- Sherine Salem (ORCID: https://orcid.org/0000-0002-9799-9687)
- Alaa Elhaddad (ORCID: https://orcid.org/0000-0003-3538-5038)
- Amr Elnashar (ORCID: https://orcid.org/0000-0001-7313-0269)
- Mahmoud Hammad (ORCID: https://orcid.org/0000-0003-1677-0360)
- Nahla El-Sharkawy
- Nessma Shahin
Institutions
- Dana-Farber Cancer Institute (US)
- National Water Research Center (EG)
- Children Cancer Hospital (EG)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fonc.2025.1661036
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00