Diagnostic efficiency of inflammatory signatures to distinguish isolated candidemia from candidemia with bacterial co-infection
The three-protein logistic regression panel (LAP-TGF beta-1, TRANCE and IL-17C) differentiated cases with isolated candidemia from those with candidemia and bacterial co-infection [AUC 0.82; 95% CI 0.629-0.968]. A three-protein inflammatory signature distinguished isolated fungal sepsis from combined bacterial-fungal sepsis. This study is the first to explore the inflammatory response to differentiate isolated candidemia from candidemia with bacterial co-infection.
Authors
- Bartosz Wojciuk (ORCID: https://orcid.org/0000-0002-2990-0323)
- Agnieszka Boroń (ORCID: https://orcid.org/0000-0003-3574-5726)
- Barbara Dołęgowska (ORCID: https://orcid.org/0000-0003-3138-1013)
- Magdalena Adamowicz (ORCID: https://orcid.org/0000-0003-0885-939X)
- Konrad Jarosz (ORCID: https://orcid.org/0000-0001-5444-5150)
- Bartłomiej Grygorcewicz (ORCID: https://orcid.org/0000-0002-0593-0069)
- Magdalena Mnichowska-Polanowska (ORCID: https://orcid.org/0000-0002-3648-0515)
- Agata Michnowska
Institutions
- Pomeranian Medical University (PL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1692077
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00