Upregulated haptoglobin in classical monocytes serves as a diagnostic and immunological biomarker in myocardial infarction: a cross-sectional multi-omics study
The HP gene is a potential diagnostic biomarker for myocardial infarction, and its specific high expression in classical monocytes implies a potential role in the pathological process of myocardial infarction by regulating the immune microenvironment. This study provides a new research direction for the diagnosis and immune-targeted therapy of myocardial infarction, and has important clinical translational value.
Authors
- Xueqi Guo
- Huibin Pan (ORCID: https://orcid.org/0000-0002-7635-3027)
- Longfei Ji (ORCID: https://orcid.org/0000-0002-1230-9051)
- Yong Li (ORCID: https://orcid.org/0000-0002-0330-657X)
- Hongwei Xu (ORCID: https://orcid.org/0000-0001-5763-3894)
- Guodong Li (ORCID: https://orcid.org/0000-0002-5163-3241)
- Chaohua Mo (ORCID: https://orcid.org/0000-0003-2550-7900)
- Binyu Wang (ORCID: https://orcid.org/0009-0005-7358-5040)
- Danfei Shi
Institutions
- Huzhou Normal University (CN)
- Third People's Hospital of Huzhou (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1707912
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00