Altered Dopamine Metabolism and Response to Treatment with Levodopa/Carbidopa in MCT8 Deficiency
Our findings confirm dopaminergic involvement in AHDS and show that levodopa/carbidopa effectively treats extrapyramidal symptoms. Further investigations could differentiate presynaptic and postsynaptic defects to optimize dopaminergic therapy. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Claudia Carducci (ORCID: https://orcid.org/0000-0003-0515-9208)
- Francesco Nicita (ORCID: https://orcid.org/0000-0002-5612-821X)
- Clara E. Antonello
- Davide Tonduti (ORCID: https://orcid.org/0000-0001-9371-7454)
- Federica Zibordi (ORCID: https://orcid.org/0000-0003-2940-5389)
- Ylenia Vaia (ORCID: https://orcid.org/0009-0009-7105-7411)
- Thomas Opladen (ORCID: https://orcid.org/0000-0003-4349-7662)
- F. Bruschi (ORCID: https://orcid.org/0000-0002-4419-7381)
- Francesco Porta (ORCID: https://orcid.org/0000-0003-3899-4867)
- Cristina Marinaccio
- Daniele Ghezzi (ORCID: https://orcid.org/0000-0002-6564-3766)
- Jacopo Sartorelli (ORCID: https://orcid.org/0009-0006-2367-6371)
- Marco Spada (ORCID: https://orcid.org/0000-0002-8894-350X)
Institutions
- University of Milan (IT)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Bambino Gesù Children's Hospital (IT)
- Ospedale Regina Margherita (IT)
- Ospedale dei Bambini Vittore Buzzi (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- University of Turin (IT)
- Heidelberg University (US)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1002/mds.70093
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00