In silico assessment of cellular damage from Lu‐177, Ac‐225, and Pb‐212 therapeutic radionuclides
Geant4-DNA simulations highlight the superior radiobiological effectiveness of alpha emitters, particularly <sup>225</sup>Ac, for inducing DNA damage and emphasize the importance of source localization. These findings enhance our understanding of TRT's radiobiological effects and can be used to support development of refined therapeutic strategies.
Authors
- Dimitris Visvikis (ORCID: https://orcid.org/0000-0003-0831-3637)
- George C. Kagadis (ORCID: https://orcid.org/0000-0002-6983-2863)
- Konstantinos Chatzipapas (ORCID: https://orcid.org/0000-0003-4006-9304)
- John D. Hazle (ORCID: https://orcid.org/0000-0003-4695-5825)
- S. Incerti (ORCID: https://orcid.org/0000-0002-0619-2053)
- Konstantinos Papachristou
Institutions
- Centre National de la Recherche Scientifique (FR)
- The University of Texas MD Anderson Cancer Center (US)
- Université de Bordeaux (FR)
- Inserm (FR)
- Université de Bretagne Occidentale (FR)
- University of Patras (GR)
- Laboratoire de Physique des deux infinis Bordeaux (FR)
- Laboratoire de Traitement de l'Information Médicale (FR)
- Delft University of Technology (NL)
Publication Details
- Journal
- Medical Physics
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1002/mp.70089
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Hellenic Foundation for Research and Innovation