Normothermic Machine Perfusion Combined With Modified Small Interfering RNA Targeting Beta-2-microglobulin and Class II Major Histocompatibility Complex Transactivator Mitigates Acute Rejection of Renal Allograft
These findings demonstrate that ex vivo NMP effectively delivers cholesterol-modified small interfering RNA to renal grafts, substantially downregulating both MHC class I and II expression and consequently attenuating AR.
Authors
- Jiang Qiu (ORCID: https://orcid.org/0000-0002-5689-7860)
- Xiaomeng Zheng
- Shuangjin Yu
- Keng‐Hsin Lan (ORCID: https://orcid.org/0000-0003-1781-0838)
- Li Lin (ORCID: https://orcid.org/0000-0002-9789-0825)
- Tong Chen (ORCID: https://orcid.org/0000-0001-7895-2077)
- Liang Tao (ORCID: https://orcid.org/0000-0002-9740-3724)
- Haiwei Chen
- Qin Wang (ORCID: https://orcid.org/0000-0001-7616-1191)
- Shicong Yang
Institutions
- Nanchang University (CN)
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Transplantation
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1097/tp.0000000000005529
- Citations
- 1
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.99