Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry
This study presents a synergistic approach integrating engineered Exo and smart biomaterials to accelerate DFU healing. The platform offers a multi-target intervention strategy with strong translational potential for the clinical management of chronic wounds.
Authors
- Nuoya Wang
- Ze-Ke Guo
- Shuangqing Wang (ORCID: https://orcid.org/0000-0003-0270-1305)
- Mingji Jin (ORCID: https://orcid.org/0000-0002-1248-6445)
- Xiuquan Quan
- L. R. Chen
- Yucai Li
- Defeng Shen (ORCID: https://orcid.org/0000-0002-6530-8837)
- Zhonggao Gao (ORCID: https://orcid.org/0000-0002-1408-5135)
- Wei Huang (ORCID: https://orcid.org/0000-0001-7004-6408)
- Teng Liu (ORCID: https://orcid.org/0000-0002-8171-5328)
- Yanru Zhao (ORCID: https://orcid.org/0009-0003-3064-8924)
- Cheng Fang (ORCID: https://orcid.org/0000-0002-6100-1715)
- Lina Jin (ORCID: https://orcid.org/0000-0002-8961-2809)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- ENN (China) (CN)
- Yanbian University Hospital (CN)
- The Medical Device (United Kingdom) (GB)
Publication Details
- Journal
- Military Medical Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s40779-025-00658-4
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81