Effectiveness of hybrid digital breast tomosynthesis/digital mammography in women presenting for routine screening at Maroondah BreastScreen, Australia: Interim analysis

Hybrid digital breast tomosynthesis (DBT)/digital mammography (DM) (mediolateral oblique from DBT with synthetic 2D, craniocaudal from DM) can potentially improve breast cancer detection and address longer DBT screen-reading time. This pre-specified interim analysis presents the first 5,000 (of target 20,000) hybrid DBT/DM screens in an ongoing prospective trial in BreastScreen Australia. Cancer detection rate for hybrid DBT/DM was 10.6/1,000 screens; recall rate was 4.2 %; median screen-reading time was 36 seconds; and mean glandular dose was 2.49 mGy. Cancer detection and recall rates for hybrid DBT/DM were consistent with DBT metrics in a previous pilot study; screen-reading time was approximately halved.