The relationship between preeclampsia subtypes and birth weight to placental weight ratio: Insights from a study of 17,709 pregnant Japanese women
The placenta plays a crucial role in preeclampsia (PE) pathogenesis, with early onset (EOPE) and late onset (LOPE) presenting with unique manifestations. In this prospective study of 17,709 pregnant Japanese women, the relationship between the PE subtype and birth weight to placental weight ratio (BW/PW ratio) was examined. EOPE was not associated with BW/PW ratio, which was consistent with reduced birth and placental weights. LOPE showed lower BW/PW ratios, indicating potential adaptive hypertrophy of the placenta. These results emphasize the consideration of PE subtypes when utilizing the BW/PW ratio as an index of placental function and to elucidate PE mechanisms.
Authors
- Taku Obara (ORCID: https://orcid.org/0000-0002-3674-1674)
- Masahiro Kikuya (ORCID: https://orcid.org/0000-0002-3080-6107)
- Keiko Murakami (ORCID: https://orcid.org/0000-0003-2103-4106)
- Hisashi Ohseto (ORCID: https://orcid.org/0000-0001-6716-9095)
- Hirohito Metoki (ORCID: https://orcid.org/0000-0002-1894-3328)
- Noriyuki Iwama (ORCID: https://orcid.org/0000-0002-6808-0911)
- Aoi Noda (ORCID: https://orcid.org/0000-0002-7644-6848)
- Mami Ishikuro (ORCID: https://orcid.org/0000-0002-2884-0023)
- Masatsugu Orui (ORCID: https://orcid.org/0000-0002-4871-8455)
- Shinichi Kuriyama (ORCID: https://orcid.org/0000-0003-2526-2974)
- Genki Shinoda
- Atsushi Hozawa
Institutions
- Tohoku Institute of Technology (JP)
- Tohoku University (JP)
- Tohoku University Hospital (JP)
- Tohoku Medical Megabank Organization (JP)
Publication Details
- Journal
- Placenta
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1016/j.placenta.2025.10.017
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06