Modified Cued Recall Test for the Diagnosis of Alzheimer's Disease in a Greek Sample of Adults With Down Syndrome: A Preliminary Study

Diagnosing Alzheimer's disease (AD) in adults with Down syndrome remains challenging due to preexisting intellectual disability (ID) and lack of specialized assessments. This was a cross-sectional multicenter study examining the capability of the Greek version of the modified Cued Recall Test (mCRT) to identify AD in DS adults. Analysis showed statistically significant negative correlations between age and scores on all mCRT measures. Statistically significant differences were detected between ID levels and all mCRT main scores and between the two diagnostic groups and performance at immediate and delayed recall. ROC analysis revealed an optimal cut-off score of 26.5 (0-36). In conclusion, mCRT is a highly sensitive tool for detecting AD in adults with DS.