Biliary stents reshape the bile microbiome in the absence of cholangitis
Endoscopic biliary stenting is associated with distinct bile microbiome alterations, characterized by enrichment of <i>Enterococcus</i> species in clinically stable patients. These findings suggest that stents may predispose to opportunistic colonization, providing a potential mechanistic link to future cholangitis. Recognizing such preclinical dysbiosis may inform tailored antimicrobial strategies and future stent design.
Authors
- Seiichiro Fukuhara (ORCID: https://orcid.org/0000-0003-1675-5670)
- Atsuto Kayashima (ORCID: https://orcid.org/0000-0002-3981-2984)
- Motohiko Kato (ORCID: https://orcid.org/0000-0002-7579-1316)
- Eisuke Iwasaki (ORCID: https://orcid.org/0000-0001-8010-5117)
- Tomohisa Sujino (ORCID: https://orcid.org/0000-0003-0699-6577)
- Kentaro Miyamoto (ORCID: https://orcid.org/0000-0001-5302-2607)
Institutions
- Keio University (JP)
- Tokyo Medical Center (JP)
- Taiho Pharmaceutical (Japan) (JP)
- BioMarin (United States) (US)
Publication Details
- Journal
- Endoscopy International Open
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1055/a-2733-3468
- Citations
- 1
- Primary Topic
- Gallbladder and Bile Duct Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Japan Society for the Promotion of Science