Anti–early antigen Epstein-Barr virus titer and atherosclerosis in relation to vascular endothelial growth factor (VEGF) polymorphism rs3025039 among older Japanese individuals
EBV EA-IgG titer was significantly positively associated with atherosclerosis only among participants who are genetically less likely to have progressive angiogenesis. An angiogenesis-related genetic factor was revealed as a determinant of the association between EBV EA-IgG titer and atherosclerosis. These findings introduce a novel concept that could explain the association between viral infection and atherosclerosis.
Authors
- Takahiro Maeda (ORCID: https://orcid.org/0000-0003-4530-6460)
- Kazuhiko Arima (ORCID: https://orcid.org/0000-0003-1149-9428)
- Seiko Nakamichi (ORCID: https://orcid.org/0000-0002-3885-3581)
- Yūji Shimizu (ORCID: https://orcid.org/0000-0002-3381-9288)
- Nagisa Sasaki
- Yuko Noguchi (ORCID: https://orcid.org/0000-0002-8163-5600)
- Hirotomo Yamanashi (ORCID: https://orcid.org/0000-0002-8655-4519)
- Shin‐ya Kawashiri (ORCID: https://orcid.org/0000-0002-2606-995X)
- Yasuhiro Nagata (ORCID: https://orcid.org/0000-0003-1353-7272)
Institutions
- Institute of Public Health (AL)
- Nagasaki University (JP)
Publication Details
- Journal
- Environmental Health and Preventive Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1265/ehpm.25-00334
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science