Comparative RNA-seq and functional assays identify L-arginine transporter SLC7A2 as a potential regulator of osteogenesis in maxillary sinus mucosal stem cells
The osteogenic differentiation of MSMSCs is tightly associated with amino acid metabolism.Notably, SLC7A2-an L-arginine transporter-is a gene required for the efficient osteogenic differentiation of MSMSCs. This study provides novel evidence to advance our understanding of the molecular mechanisms underlying stem cell osteogenic differentiation during maxillary sinus floor lifting surgery,and further suggests that SLC7A2 may serve as a potential target to enhance the efficacy of MSMSCs-based bone regeneration.
Authors
- Ningbo Geng (ORCID: https://orcid.org/0000-0002-0809-7463)
- Tianren Zhou
- Chunhui Liao
- Sungsoon Mo (ORCID: https://orcid.org/0000-0002-0109-258X)
- Chi Zhang (ORCID: https://orcid.org/0000-0001-7636-0377)
- Songling Chen (ORCID: https://orcid.org/0000-0001-7315-2142)
- Wei Peng (ORCID: https://orcid.org/0000-0002-8031-8208)
- Jing Ren (ORCID: https://orcid.org/0009-0005-9787-3100)
Institutions
- Sun Yat-sen University (CN)
- Guangzhou Women and Children Medical Center (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fgene.2025.1701001
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sun Yat-sen University
- Natural Science Foundation of Guangdong Province
- Traditional Chinese Medicine Bureau of Guangdong Province
- Guangzhou Municipal Science and Technology Project