IgG4-Positive Conjunctival Tumor with Systemic Allergy: A Case Report

This case highlights isolated allergic conjunctivitis as a manifestation of IgG4-related disease, underscoring the critical need for comprehensive evaluation in patients enduring conjunctival symptoms. Surgical excision of the conjunctival lesions alleviated tissue compression, yielding a resolution of symptoms; this intervention was complemented by postoperative topical corticosteroid therapy. Substantiating the link between tumor formation and IgG4-RD demands further case evidence. Even in instances of isolated conjunctival IgG4-related ophthalmic disease (IgG4-ROD), a persistent risk of multi-organ involvement emerges over time, making long-term follow-up and vigilant observation imperative.

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Publication Details

Journal
Ocular Immunology and Inflammation
Published
2025-10-27
DOI
https://doi.org/10.1080/09273948.2025.2577654
Primary Topic
IgG4-Related and Inflammatory Diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

IgG4-Positive Conjunctival Tumor with Systemic Allergy: A Case Report

Fuling Liu, Bin Yuan, Yuxuan Deng, Lin Luo et al.
Ocular Immunology and Inflammation
IgG4-Related and Inflammatory Diseases
article

IgG4-Positive Conjunctival Tumor with Systemic Allergy: A Case Report

Fuling Liu, Bin Yuan, Yuxuan Deng, Lin Luo, Zhanyu Zhou, Juan Zhang
article en

Abstract

This case highlights isolated allergic conjunctivitis as a manifestation of IgG4-related disease, underscoring the critical need for comprehensive evaluation in patients enduring conjunctival symptoms. Surgical excision of the conjunctival lesions alleviated tissue compression, yielding a resolution of symptoms; this intervention was complemented by postoperative topical corticosteroid therapy. Substantiating the link between tumor formation and IgG4-RD demands further case evidence. Even in instances of isolated conjunctival IgG4-related ophthalmic disease (IgG4-ROD), a persistent risk of multi-organ involvement emerges over time, making long-term follow-up and vigilant observation imperative.

Ocular Immunology and InflammationVol. 33(10)
Qingdao University (CN), Affiliated Hospital of Qingdao University (CN), Qingdao Women and Children's Hospital (CN)
Openalex Percentile: Top 55%
IgG4-Related and Inflammatory Diseases
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IgG4-Positive Conjunctival Tumor with Systemic Allergy: A Case Report — Fuling Liu, Bin Yuan, et al. · Ocular Immunology and Inflammation (2025) | TGRS Research Map | TGRS