Selective impact of zinc on human circulating CD56dim NK cells

Extracellular zinc selectively activates CD56<sup>dim</sup> NK cells enhancing degranulation and IFNγ production. Zinc supplementation might be a useful tool for in vitro NK cell expansion protocols for future cellular therapies.

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Publication Details

Journal
Journal of Trace Elements in Medicine and Biology
Published
2025-10-27
DOI
https://doi.org/10.1016/j.jtemb.2025.127788
Primary Topic
Trace Elements in Health
Type
article
Field-Weighted Citation Impact
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article

Selective impact of zinc on human circulating CD56dim NK cells

Jana Jakobs, Lothar Rink, Sabrina B. Bennstein, Ronja Stöcker et al.
Journal of Trace Elements in Medicine and Biology
Trace Elements in Health
article

Selective impact of zinc on human circulating CD56dim NK cells

Jana Jakobs, Lothar Rink, Sabrina B. Bennstein, Ronja Stöcker, Laura Heenen, Kim Ohl
article en

Abstract

Extracellular zinc selectively activates CD56<sup>dim</sup> NK cells enhancing degranulation and IFNγ production. Zinc supplementation might be a useful tool for in vitro NK cell expansion protocols for future cellular therapies.

Journal of Trace Elements in Medicine and BiologyVol. 92
RWTH Aachen University (DE)
Openalex Percentile: Top 62%
Trace Elements in Health
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