CD70-Targeting CAR NK Cells Overcome BCMA Downregulation and Improve Survival in High-risk Multiple Myeloma Models
We demonstrate that CD70 expression is elevated in patients with high-risk multiple myeloma and in patients with t(4;14) translocation. CD70-targeting CAR NK cells exhibit potent cytotoxicity against CD70+ multiple myeloma cells and significantly improve survival in xenograft mouse models of multiple myeloma, even in the absence of BCMA expression. See related commentary by Benson Jr and Caligiuri, p. 166.
Authors
- Ana Karen Nunez Cortes (ORCID: https://orcid.org/0000-0001-5380-9274)
- Luz Yurany Moreno Rueda (ORCID: https://orcid.org/0000-0002-9632-7934)
- Luciana Melo Garcia (ORCID: https://orcid.org/0000-0002-9148-2193)
- Katayoun Rezvani (ORCID: https://orcid.org/0000-0002-9599-2246)
- Nadima Uprety (ORCID: https://orcid.org/0000-0003-4379-6208)
- Gary Deyter (ORCID: https://orcid.org/0000-0003-2638-0825)
- Luis Muniz-Feliciano (ORCID: https://orcid.org/0009-0000-7096-0064)
- Muzaffar H. Qazilbash (ORCID: https://orcid.org/0000-0003-2876-2886)
- Sunil Acharya (ORCID: https://orcid.org/0000-0002-3907-9321)
- Corry M. Jones (ORCID: https://orcid.org/0009-0007-7028-9160)
- April L. Gilbert (ORCID: https://orcid.org/0000-0002-8626-1919)
- Rafet Başar (ORCID: https://orcid.org/0000-0003-4713-0454)
- Seema Rawal (ORCID: https://orcid.org/0009-0000-0963-2870)
- David Marín (ORCID: https://orcid.org/0000-0003-0812-9346)
- Robert Zygmunt Orlowski (ORCID: https://orcid.org/0000-0002-5723-4129)
- Pinaki P. Banerjee (ORCID: https://orcid.org/0009-0003-6711-3034)
- Hans Chulhee Lee (ORCID: https://orcid.org/0000-0001-8545-3292)
- Richard E. Champlin (ORCID: https://orcid.org/0000-0002-4314-5037)
- Vernikka Woods (ORCID: https://orcid.org/0009-0002-0661-3636)
- Elizabeth J. Shpall (ORCID: https://orcid.org/0000-0003-3947-4126)
- Rejeena Shrestha (ORCID: https://orcid.org/0000-0001-7642-6735)
- Krina K. Patel (ORCID: https://orcid.org/0000-0002-8894-027X)
- May Daher (ORCID: https://orcid.org/0000-0002-6026-8397)
- Paul Lin (ORCID: https://orcid.org/0000-0002-0524-267X)
- Dexing Fang (ORCID: https://orcid.org/0009-0003-9328-1250)
- Francia Reyes-Silva (ORCID: https://orcid.org/0009-0001-5396-7691)
- Chenyu Zhang (ORCID: https://orcid.org/0000-0001-7498-1751)
- Ping Li (ORCID: https://orcid.org/0009-0005-7961-7453)
- Pei Lin (ORCID: https://orcid.org/0000-0002-9844-945X)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Baylor College of Medicine (US)
- Université Laval (CA)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1158/2643-3230.bcd-25-0130
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Conquer Cancer Foundation
- Multiple Myeloma Research Foundation
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- American Society of Clinical Oncology
- Johns Hopkins University
- National Institutes of Health
- University of Texas MD Anderson Cancer Center