Stillbirth in intrahepatic cholestasis of pregnancy and timing of severely elevated bile acid concentrations: an observational cohort study
A later gestation at which serum bile acids first rise over 100 μmol/L, and a later gestation at which bile acid concentration peaks, are both associated with a higher risk of stillbirth. A marked increase in bile acid concentration immediately prior to stillbirth may herald increased risk. These findings underline the benefit of repeat testing and surveillance of serum bile acids to support individualized recommendations regarding birth gestation.
Authors
- Peter Dixon (ORCID: https://orcid.org/0000-0002-0197-2632)
- Agata Majewska (ORCID: https://orcid.org/0000-0001-8071-0368)
- Victoria Geenes (ORCID: https://orcid.org/0000-0002-0226-7636)
- Paul T. Seed (ORCID: https://orcid.org/0000-0001-7904-7933)
- Catherine Williamson (ORCID: https://orcid.org/0000-0002-6226-7611)
- Amy P Worrall (ORCID: https://orcid.org/0000-0002-7417-1844)
- Jenny Chambers (ORCID: https://orcid.org/0000-0001-6022-1719)
- Caroline Ovadia (ORCID: https://orcid.org/0000-0002-4859-0324)
Institutions
- Royal Veterinary College (GB)
- King's College London (GB)
- MRC Centre for Reproductive Health (GB)
- King's College School (GB)
- Imperial College London (GB)
Publication Details
- Journal
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1016/j.ejogrb.2025.114800
- Primary Topic
- Pediatric Hepatobiliary Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- NHS Blood and Transplant
- Wellcome Trust
- NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
- National Institute for Health and Care Research
- Department of Health and Social Care
- King's Health Partners
- Tommy's
- NIHR BioResource