Differential heterologous immunological effects induced by ChAdOx1-S and BNT162b2 COVID-19 vaccines
Our study findings provide additional support to the hypothesis that mRNA- and adenovirus-based vaccines differ in their broad immunological effects. Specifically, our observation that adenovirus-based vaccination tends to result in higher pro-inflammatory cytokine responses might help explain the difference in the heterologous effects of the two types of vaccines. Knowledge about NSEs is increasingly important for making public health and policy decisions, particularly for vulnerable populations.
Authors
- Martijn Zoodsma (ORCID: https://orcid.org/0000-0003-3636-2209)
- Elisabeth A. Dulfer (ORCID: https://orcid.org/0000-0002-9049-7318)
- Leonie S. Helder
- Yang Li (ORCID: https://orcid.org/0000-0002-8239-3279)
- Jorge Domínguez‐Andrés (ORCID: https://orcid.org/0000-0002-9091-1961)
- J. Maat (ORCID: https://orcid.org/0000-0001-7392-8393)
- Büsra Geckin (ORCID: https://orcid.org/0000-0002-4751-4960)
- Wenchao Li (ORCID: https://orcid.org/0000-0002-7956-0742)
- Reinout van Crevel
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Centre for Individualised Infection Medicine (DE)
Publication Details
- Journal
- Cellular Immunology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1016/j.cellimm.2025.105038
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ZonMw