Interaction of tumor cells and Cancer-associated fibroblasts in radiation-induced senescence
This study demonstrates that CAFs modulate tumor cell senescence and enhance migration following irradiation. These findings highlight the role of CAFs in progression and radiation response. Targeting CAF-related mechanisms during radiotherapy may improve therapeutic outcomes across epithelial cancer types.
Authors
- Johannes Raphael Kupka (ORCID: https://orcid.org/0000-0003-1304-315X)
- Nadine Wiesmann (ORCID: https://orcid.org/0000-0001-5661-6953)
- Victoria Langer
- Rita Gieringer
- Sebahat Kaya
- Jürgen Brieger
Institutions
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
Publication Details
- Journal
- Cellular Signalling
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1016/j.cellsig.2025.112187
- Citations
- 1
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 1.16