Repertoire and clinical hierarchy of AR locus alterations in castration-resistant prostate cancer
This study provides the most comprehensive resource to date characterizing somatic alterations at the AR locus. Our clinicogenomic analysis establishes the repertoire and clinical relevance of AR genotypes in mCRPC, informing efforts to target renewed AR dependency.
Authors
- Kim van der Zande
- Corinne Maurice‐Dror (ORCID: https://orcid.org/0000-0003-4455-4497)
- Daygen L. Finch
- E. Winquist
- Wilbert Zwart (ORCID: https://orcid.org/0000-0002-9823-7289)
- Chia-Chi Flora Huang (ORCID: https://orcid.org/0000-0002-2150-3139)
- Nathan A. Lack (ORCID: https://orcid.org/0000-0001-7399-5844)
- Sofie H. Tolmeijer (ORCID: https://orcid.org/0000-0003-4066-885X)
- Ivan Pak Lok Yu
- Joanna Vergidis
- Aaron R. Hansen (ORCID: https://orcid.org/0000-0002-2363-8707)
- Wei Tu (ORCID: https://orcid.org/0000-0002-0255-4037)
- Joonatan Sipola (ORCID: https://orcid.org/0000-0003-1438-9988)
- Jack V. W. Bacon
- Tuomo Virtanen (ORCID: https://orcid.org/0009-0003-1201-6077)
- Jimmy L. Zhao (ORCID: https://orcid.org/0000-0001-5361-6894)
- Jean‐Michel Lavoie (ORCID: https://orcid.org/0000-0001-5344-8341)
- Andries M. Bergman (ORCID: https://orcid.org/0000-0001-5223-2549)
- Christopher E. Barbieri (ORCID: https://orcid.org/0000-0002-0381-1947)
- Constantine Si Lun Tam (ORCID: https://orcid.org/0000-0002-9759-5017)
- Niven Mehra (ORCID: https://orcid.org/0000-0002-4794-1831)
- Michael Ong (ORCID: https://orcid.org/0000-0002-0347-5541)
- Daniel Khalaf (ORCID: https://orcid.org/0000-0001-6329-2678)
- Mariam Jafri
- Nielka P. van Erp (ORCID: https://orcid.org/0000-0003-1553-178X)
- Matti Annala (ORCID: https://orcid.org/0000-0001-8478-9026)
- David A. Quigley (ORCID: https://orcid.org/0000-0002-4726-1473)
- D. Rathkopf
- Alexander W. Wyatt (ORCID: https://orcid.org/0000-0003-2399-0329)
- Jussi Nikkola (ORCID: https://orcid.org/0000-0002-5077-2012)
- April A. N. Rose (ORCID: https://orcid.org/0000-0002-9845-4603)
- Gillian Vandekerkhove (ORCID: https://orcid.org/0000-0001-5606-0908)
- Sébastien J. Hotte (ORCID: https://orcid.org/0000-0001-9286-1972)
- Matti Nykter (ORCID: https://orcid.org/0000-0001-6956-2843)
- Michael Kolinsky (ORCID: https://orcid.org/0000-0002-3937-3782)
- Krista Noonan (ORCID: https://orcid.org/0000-0002-2185-844X)
- C. Bernales
- Konsta Kukkonen (ORCID: https://orcid.org/0000-0001-5819-933X)
- Kinnari H. Parekh (ORCID: https://orcid.org/0000-0002-1566-2846)
- Lucia Nappi (ORCID: https://orcid.org/0000-0002-4365-7251)
- Christian Kollmannsberger (ORCID: https://orcid.org/0000-0002-6329-761X)
- Bernhard J. Eigl (ORCID: https://orcid.org/0000-0003-1653-6929)
- Edmond M. Kwan (ORCID: https://orcid.org/0000-0002-7053-680X)
- Muhammad Zulfiqar (ORCID: https://orcid.org/0000-0001-9027-6913)
- Gráinne Donnellan (ORCID: https://orcid.org/0009-0002-7373-7567)
- Anna Riminchan
- Lauri Ryyppö
- Mohammad Soleimani (ORCID: https://orcid.org/0000-0002-8270-9499)
- S. Miller (ORCID: https://orcid.org/0000-0003-3649-2927)
- K.N. Chi
- Som D. Mukherjee
- R Gagnon
- Sunil Parimi (ORCID: https://orcid.org/0000-0003-2588-6162)
- E Hardy (ORCID: https://orcid.org/0000-0002-8910-6332)
- Adelia (ORCID: https://orcid.org/0009-0007-1490-8131)
- Y Takieldeen (ORCID: https://orcid.org/0009-0007-9757-1545)
- E Sartori-Mueller
Institutions
- Interior Health (CA)
- Ontario Institute for Cancer Research (CA)
- BC Cancer Agency (CA)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- Memorial Sloan Kettering Cancer Center (US)
- University of British Columbia (CA)
- Radboud University Nijmegen (NL)
- Tampere University of Applied Sciences (FI)
- Tampere University (FI)
- Cancer Council Victoria (AU)
- Queen's University (CA)
- Cornell University (US)
- Juravinski Cancer Centre (CA)
- Ottawa Hospital (CA)
- London Health Sciences Centre (CA)
- Jewish General Hospital (CA)
- Health Sciences Centre (CA)
- Princess Margaret Cancer Centre (CA)
- Radboud University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- EndoGastric Solutions (United States) (US)
- Aimmune Therapeutics (United Kingdom) (GB)
- Eastern Health (AU)
- Victorian Comprehensive Cancer Centre (AU)
- Abbotsford Veterinary Clinic (CA)
- Mount Vernon Cancer Centre (GB)
- Prostate Cancer Research (GB)
- Occupational Cancer Research Centre (CA)
- Oncode Institute (NL)
- Surrey Place Centre (CA)
- Tampere University (FI)
- Canadian Centre for Applied Research in Cancer Control (CA)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- Weill Cornell Medicine (US)
- Ottawa Hospital Research Institute (CA)
- Indiana University School of Medicine
- Indiana University (US)
- Hamilton Health Sciences (CA)
- McMaster University (CA)
Publication Details
- Journal
- Annals of Oncology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1016/j.annonc.2025.10.1236
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52