Cytomegalovirus reactivation in mechanically ventilated patients with or without SARS-CoV-2 infection: A retrospective cohort study
In this large retrospective cohort, CMV reactivation was not significantly associated with SARS-CoV-2 infection in patients undergoing invasive mechanical ventilation for at least 4 days. The major risk factor for CMV reactivation was treatment with methylprednisolone. The combination of CMV reactivation with SARS-CoV-2 infection was associated with a higher mortality whereas ganciclovir treatment reduced mortality.
Authors
- Rémi N. Charrel (ORCID: https://orcid.org/0000-0002-7675-8251)
- Vanessa Pauly (ORCID: https://orcid.org/0000-0003-1346-1781)
- Paul-Rémi Petit (ORCID: https://orcid.org/0000-0002-4743-3626)
- Sami Hraiech (ORCID: https://orcid.org/0000-0003-4652-1664)
- Christine Zandotti
- Octave Cannac
- Léa Lucıanı (ORCID: https://orcid.org/0000-0002-0738-5957)
- Geoffray Agard (ORCID: https://orcid.org/0000-0002-5095-6268)
- Laurent Papazian (ORCID: https://orcid.org/0000-0002-8125-9406)
- Xavier de Lamballerie
- Damien Barrau (ORCID: https://orcid.org/0009-0007-8661-0094)
Institutions
- Ceres (US)
- Inserm (FR)
- Aix-Marseille Université (FR)
- Assistance Publique Hôpitaux de Marseille (FR)
- Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (FR)
- Hôpital Nord (FR)
- Institut Régional d'Administration de Bastia (FR)
- Centre d'Études et de Recherches sur les Qualifications (FR)
- Laboratoire de Chimie Bactérienne (FR)
- Institut de Recherche pour le Développement (FR)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1371/journal.pone.0328494
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00