Novel niclosamide stearate prodrug therapeutic shows potential efficacy against naturally occurring canine osteosarcoma in a clinical feasibility study
These results suggest that niclosamide-when transformed into the highly bioavailable NSPT-may have potential as a novel therapeutic agent for treating OS.
Authors
- David Needham (ORCID: https://orcid.org/0000-0002-0082-9148)
- Jason A. Somarelli (ORCID: https://orcid.org/0000-0003-1510-9343)
- William C. Eward (ORCID: https://orcid.org/0000-0002-4553-1943)
- Brian E. Brigman (ORCID: https://orcid.org/0000-0003-3835-048X)
- Steven E. Suter (ORCID: https://orcid.org/0000-0002-4972-3571)
- Hailey E. Brighton
- Julia D. Visgauss (ORCID: https://orcid.org/0000-0002-0512-1763)
- Sin-Ho Jung
- Mark M. Cullen (ORCID: https://orcid.org/0000-0003-1322-4858)
- Kristina Pavić (ORCID: https://orcid.org/0000-0002-8523-6340)
- Ivan Spasojević (ORCID: https://orcid.org/0000-0001-9890-6246)
Institutions
- North Carolina State University (US)
- University of Nottingham (GB)
- Duke University (US)
- University of Zagreb (HR)
- Duke University Hospital (US)
Publication Details
- Journal
- American Journal of Veterinary Research
- Published
- 2025-10-27
- DOI
- https://doi.org/10.2460/ajvr.24.06.0176
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00