Survival outcomes and prognostic factors in children and adults with medulloblastoma from a Latin America country: A retrospective cohort
Both populations demonstrated similar survival rates that were comparable to or lower than those reported in previous studies. In adults, performance status and radiotherapy were prognostic factors for DFS, while histologic type and radiotherapy for OS. In children, chemotherapy and radiotherapy were prognostic factors for DFS, and performance status was the only OS prognostic factor. These findings underscore the importance of optimizing treatment adherence and completing standard therapies, as well as improving staging practices, to enhance outcomes in real-world settings.
Authors
- Bryan Valcárcel (ORCID: https://orcid.org/0000-0003-3853-2603)
- Rosdali Díaz Coronado (ORCID: https://orcid.org/0000-0002-1849-2256)
- Michael Mallouh (ORCID: https://orcid.org/0009-0002-9277-6094)
- Daniel Enríquez (ORCID: https://orcid.org/0000-0002-0855-8936)
- Juan Varas (ORCID: https://orcid.org/0000-0001-5254-6206)
- Gabriel De la Cruz Ku (ORCID: https://orcid.org/0000-0003-4203-3890)
- Diego Chambergo‐Michilot (ORCID: https://orcid.org/0000-0002-3904-7514)
- Jhajaira M. Araujo (ORCID: https://orcid.org/0000-0002-9639-8070)
- Victor Castro Oliden (ORCID: https://orcid.org/0000-0003-2828-7325)
- J. Smith Torres‐Roman (ORCID: https://orcid.org/0000-0001-5310-6077)
- Renato Luque-Benavides (ORCID: https://orcid.org/0000-0003-0819-6258)
- Flavia Rioja
- Martin Hemeryth
Institutions
- University of Massachusetts Chan Medical School (US)
- George Washington University (US)
- Universidad Peruana Cayetano Heredia (PE)
- Universidad Privada San Juan Bautista (PE)
- Universidad Científica del Sur (PE)
- Instituto Nacional de Enfermedades Neoplásicas (PE)
- EsSALUD (PE)
- Universidad Tecnológica del Perú (PE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1371/journal.pone.0333611
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad Científica del Sur