Ambroxol is Effective for Corneal Pain in Rats
Selective blockage of key nociceptors of the cornea by ambroxol is effective in suppressing corneal pain and heightened nociceptor excitability, leading to modulation of NCP. Sparing certain CS could translate into more protection to the ocular surface. No overt toxicity of ambroxol was seen in cultured human corneal epithelial cells in this study.
Authors
- Xiaoxiao Guo (ORCID: https://orcid.org/0000-0002-8583-5992)
- Guigang Li
- Eugene M. Wang
- Ao-Ling Li
- Qi Pu (ORCID: https://orcid.org/0000-0002-3729-5979)
- Xinyu Li (ORCID: https://orcid.org/0000-0002-5908-6676)
- Xuejiao Chang (ORCID: https://orcid.org/0000-0002-6089-390X)
- Mingwu Wang (ORCID: https://orcid.org/0000-0003-0259-3607)
Institutions
- University of Arizona (US)
- intuVision (United States) (US)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- University of Rochester (US)
Publication Details
- Journal
- Journal of Ocular Pharmacology and Therapeutics
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1177/10807683251391936
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00