THE ROLE OF INFLAMMATORY INDICES IN THE PROGRESSION OF ATRIAL FIBRILLATION

Structural and functional changes in internal organs in chronic non-infectious diseases: possibilities for drug correction" (state registration number 0121U108893). Introduction.Atrial fibrillation (AF) is the most common clinically significant cardiac arrhythmia and accounts for a significant proportion of the cardiovascular disease epidemic in the 21st century [1].AF is known to be associated with increased morbidity and mortality, placing a heavy burden on the healthcare system.This arrhythmia carries numerous risks, including a twofold increase in the incidence of myocardial infarction, a fivefold increase in the incidence of stroke and heart failure, as well as dementia and other cognitive impairments.Moreover, AF is associated with a 3.0-fold and 2.5-fold increase in the risk of all-cause mortality and sudden cardiac death, respectively [1].The lifetime risk of developing AF is approximately 1 in 3-5 people after the age of 45.Over the last decade, the global prevalence of arrhythmia has increased significantly from 33.5 million to 59 million people [2].The burden of AF is projected to increase by >60% by 2050 [3].