Green Synthesis, Chemical Characterization, and Antiproliferative Effect of Gold Nanoparticles Using Methanolic Extracts of <i>Chrysophyllum cainito</i> L. Peels

The article's aim was thus to evaluate the antiproliferative activity of gold nanoparticles associated with the methanolic extract of <i>Chrysophyllum cainito</i> in human breast cancer cell line (MCF-7), cervical cancer tissue (HeLa), and colorectal cancer cell line (HCT-116) cancer cell lines. The methanolic extract showed the presence of polyphenols and organic acids related to anticancer properties. In relation to the gold nanoparticles functionalized with the methanolic extract of <i>C. cainito</i> peels, these nanoparticles showed significant cytotoxic activity (<i>p = .0001</i>) in the HCT-116 cell line at 72 h after exposure to these. We consider this the first contribution to the use of the methanolic extract of <i>C. cainito</i> for the green synthesis of gold nanoparticles. In conclusion, the green synthesis of gold nanoparticles associated with <i>C. cainito</i> methanolic peel extract may be an interesting option for the search for new cancer treatments.