Integrative GWAS and RNA-Seq analysis for target identification and virtual drug screening in colorectal cancer
This study identified CRC-linked genes through GWASs and transcriptomics, highlighting their prognostic and druggable relevance. Computational drug repurposing pinpoints PYGL inhibitors as promising candidates, offering a translational framework for CRC therapy development.
Authors
- Yu Lei (ORCID: https://orcid.org/0000-0002-0011-1515)
- Qinghui Liu (ORCID: https://orcid.org/0009-0006-0237-4163)
- Zixuan Liu (ORCID: https://orcid.org/0000-0002-4728-4149)
- Jiale Han (ORCID: https://orcid.org/0009-0004-9865-7816)
Institutions
- HBIS (China) (CN)
- Hebei Science and Technology Department (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1371/journal.pone.0333179
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.00