Circadian rhythm parameters differentiate euthymic, manic and depressive mood states in bipolar disorders – an explorative pilot study
Circadian rhythm parameters can effectively differentiate mood states in BD, highlighting their potential as clinical markers for episode transitions. Although the study was explorative by nature, the findings emphasize the potential value of integrating circadian biomarkers into digital phenotyping for mood state monitoring. Future studies should explore extended monitoring periods, larger samples, and real-time feedback systems to improve early intervention and personalized treatment strategies in BD.
Authors
- Esther Mühlbauer (ORCID: https://orcid.org/0000-0001-7550-8552)
- Andreas B. Neubauer (ORCID: https://orcid.org/0000-0003-0515-1126)
- Philipp Ritter (ORCID: https://orcid.org/0000-0003-4286-5830)
- Julia Clemens (ORCID: https://orcid.org/0000-0002-5353-7894)
- Ulrich Ebner‐Priemer (ORCID: https://orcid.org/0000-0002-2769-5944)
- Iris Reinhard (ORCID: https://orcid.org/0000-0001-8215-1678)
- Vera Miriam Ludwig (ORCID: https://orcid.org/0000-0002-8475-8972)
- Sara Elena Schmitz (ORCID: https://orcid.org/0000-0003-4496-7398)
- Michael Bauer (ORCID: https://orcid.org/0000-0002-4819-0419)
- W. Emanuel Severus
Institutions
- Karlsruhe Institute of Technology (DE)
- King's College London (GB)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Central Institute of Mental Health (DE)
- University Hospital Carl Gustav Carus (DE)
- Asklepios Kliniken Hamburg (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- International Journal of Bipolar Disorders
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s40345-025-00396-5
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft