White Matter Hyperintensities Moderate the Association Between Diabetes and Non-AD Brain Atrophy
Our study demonstrated diabetes and WMHs synergistically contribute to brain atrophy independent of AD, suggesting diabetes-associated cognitive impairment is primarily driven by cerebrovascular disease rather than Alzheimer pathology.
Authors
- Narayanaswamy Venketasubramanian (ORCID: https://orcid.org/0000-0003-3593-6362)
- Wei Ying Tan (ORCID: https://orcid.org/0000-0003-3271-887X)
- Joyce Ruifen Chong (ORCID: https://orcid.org/0000-0002-2869-0096)
- Saima Hilal (ORCID: https://orcid.org/0000-0001-5434-5635)
- Eddie Chong (ORCID: https://orcid.org/0009-0006-5818-1635)
- Mitchell K.P. Lai (ORCID: https://orcid.org/0000-0001-7685-1424)
- Zhaojun Liu (ORCID: https://orcid.org/0000-0001-8954-4052)
- Christopher Chen (ORCID: https://orcid.org/0000-0001-5130-0079)
- Jiangbo Cui (ORCID: https://orcid.org/0000-0003-4403-4248)
- Shin Hui On
Institutions
- National University of Singapore (SG)
- Raffles Institution (SG)
- China-Japan Friendship Hospital (CN)
- National University Health System (SG)
Publication Details
- Journal
- Diabetes Care
- Published
- 2025-10-27
- DOI
- https://doi.org/10.2337/dc25-1162
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00