Expanded adaptive NKG2C+ NK cells exhibit potent ADCC and functional responses against HBV-infected hepatoma cell lines
Our study demonstrates the first successful expansion of adaptive NK cells with robust functional responses from donors with chronic viral infection. This approach creates opportunities for NK cell-based therapies alone or in combination with monoclonal antibodies contributing to HBV functional cure strategies and the treatment of HBV-driven cancers.
Authors
- Mark W. Lowdell (ORCID: https://orcid.org/0000-0002-2600-5024)
- Kelly da Costa (ORCID: https://orcid.org/0000-0001-6352-3843)
- Anucha Preechanukul (ORCID: https://orcid.org/0000-0001-7428-0058)
- Patrick T.F. Kennedy (ORCID: https://orcid.org/0000-0001-9201-0094)
- Fiona M. Burns (ORCID: https://orcid.org/0000-0002-9105-2441)
- Jessica Davies
- Ebba Sohlberg (ORCID: https://orcid.org/0000-0003-1942-0040)
- Noshin Hussain (ORCID: https://orcid.org/0000-0001-9363-8174)
- Sadiyah Mukhtar
- Xiaodong Zhuang (ORCID: https://orcid.org/0000-0002-6870-9003)
- Helena Arellano-Ballestero (ORCID: https://orcid.org/0009-0001-3931-8636)
- Upkar S. Gill (ORCID: https://orcid.org/0000-0001-6146-9708)
- Karl‐Johan Malmberg (ORCID: https://orcid.org/0000-0002-8718-9373)
- Douglas MacDonald (ORCID: https://orcid.org/0000-0002-3369-8754)
- Dimitra Peppa (ORCID: https://orcid.org/0000-0002-9281-5471)
- Mala K. Maini (ORCID: https://orcid.org/0000-0001-6384-1462)
- Jonida Kokiçi (ORCID: https://orcid.org/0009-0000-3773-492X)
- Thomas Fernandez
- Sabine Kinloch
- Benjamin Hammond
Institutions
- Queen Mary University of London (GB)
- Royal Free London NHS Foundation Trust (GB)
- Barts Health NHS Trust (GB)
- The Royal Free Hospital (GB)
- Karolinska Institutet (SE)
- Mortimer Market Centre (GB)
- CRUK Lung Cancer Centre of Excellence (GB)
- University College London (GB)
Publication Details
- Journal
- Cytotherapy
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1016/j.jcyt.2025.10.006
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- UK Research and Innovation
- Rosetrees Trust
- National Institutes of Health
- Medical Research Council