The ATP-mediated cytokine release by macrophages is down-modulated by unconventional α9* nicotinic acetylcholine receptors
We conclude that the cholinergic control of ATP-mediated IL-1β release is active in human monocytes and in macrophages and that nAChR agonists can also regulate the release of IL-18 and IL-1α. This mechanism specifically regulates the ATP-induced cytokine release, without suppressing ATP-independent cytokine release. Thus, unconventional α9* nAChRs are promising therapeutic targets for ATP-induced inflammatory diseases, including sterile hyperinflammation.
Authors
- Dennis Hanke (ORCID: https://orcid.org/0000-0002-3594-4234)
- Vijay Kumar Singh (ORCID: https://orcid.org/0000-0002-4932-3076)
- Anca‐Laura Amati
- Veronika Grau (ORCID: https://orcid.org/0000-0001-7512-2051)
- Ulrike A. Nuber (ORCID: https://orcid.org/0000-0002-7268-4136)
- Katrin Richter (ORCID: https://orcid.org/0000-0002-2450-1083)
- Juliane Liese
- Philipp Wolf
- Marius Rohde (ORCID: https://orcid.org/0000-0002-1487-525X)
- J. Michael McIntosh (ORCID: https://orcid.org/0000-0001-9939-7981)
- Andreas Hecker (ORCID: https://orcid.org/0000-0001-9701-7586)
- H. Keller
- Kathrin Büttner
- Sybille Mazurek (ORCID: https://orcid.org/0000-0002-9104-7677)
- Luca J. Ettischer
- Laura Teppe
- Faeq Husain-Syed
Institutions
- Hochschule Bonn-Rhein-Sieg (DE)
- Justus-Liebig-Universität Gießen (DE)
- University of Utah (US)
- Universitätsklinikum Gießen und Marburg (DE)
- Technische Universität Darmstadt (DE)
- George E. Wahlen Department of VA Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1661114
- Citations
- 1
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- Precursory Research for Embryonic Science and Technology