A clinically applicable method for early interstitial lung disease detection in incident rheumatoid arthritis cases: integration of protein biomarkers and clinical factors
This systematic study from discovery to validation identified MMP3 and VWF as potential biomarkers for RA-ILD. The integrated predictive model combining these biomarkers with clinical parameters (KL-6, age, sex) provides a potential tool for early ILD screening in RA patients, offering novel strategies for early diagnosis and intervention of RA-ILD.
Authors
- Juanjuan Chen (ORCID: https://orcid.org/0000-0002-6199-7807)
- Yuanfang Tan (ORCID: https://orcid.org/0000-0002-0512-9837)
- Huiyuan Chen (ORCID: https://orcid.org/0000-0002-3927-4119)
- Qiuying Fan (ORCID: https://orcid.org/0009-0001-0985-6521)
- Xi Gou (ORCID: https://orcid.org/0009-0004-5609-9465)
- Y Liu (ORCID: https://orcid.org/0009-0005-3700-9249)
- Hui Liu (ORCID: https://orcid.org/0009-0000-5568-4153)
- Wei Jiao
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Inner Mongolia Medical University (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1080/07853890.2025.2576636
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00