Single local injection of 3S-HMGB1 enhances early bone healing and titanium implant osseointegration in type 2 diabetic mice
Collectively, our findings indicate that a single injection of redox-stable 3S-HMGB1 may represent a promising regenerative strategy to mitigate early implant failure in diabetes. Future studies should explore sustained delivery approaches to enhance long-term outcomes.
Authors
- Gustavo Pompermaier Garlet (ORCID: https://orcid.org/0000-0002-5071-8382)
- Evelin Rios (ORCID: https://orcid.org/0000-0003-3165-128X)
- Cláudia Cristina Biguetti (ORCID: https://orcid.org/0000-0003-4503-3108)
- Bhuvana Lakkasetter Chandrashekar (ORCID: https://orcid.org/0000-0001-9059-2844)
- Danieli C. Rodrigues (ORCID: https://orcid.org/0000-0002-0389-0833)
- Alexandra Arteaga (ORCID: https://orcid.org/0000-0002-8610-5860)
- Jimena Mora (ORCID: https://orcid.org/0009-0005-7016-9818)
Institutions
- The University of Texas at Dallas (US)
- Universidade de São Paulo (BR)
- The University of Texas Rio Grande Valley (US)
- Universidade Brasil (BR)
- University of North Texas at Dallas (US)
Publication Details
- Journal
- Journal of Applied Oral Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1590/1678-7757-2025-0358
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00