MiR-24-3p delivered by adipose derived stem cells exosomes alleviate macrophage pyroptosis via NLRP3/Caspase1/GSDMD in sepsis ALI
Our findings indicate that ADSCs-exo attenuates ALI by modulating macrophage pyroptosis through the miR-24-3p/NLRP3/Caspase1/GSDMD axis, thereby presenting a promising therapeutic approach for sepsis-associated ALI.
Authors
- Xianqi Wang
- Haian Fu (ORCID: https://orcid.org/0000-0002-2362-7979)
- Dahai Hu (ORCID: https://orcid.org/0000-0001-5543-092X)
- Jin Li (ORCID: https://orcid.org/0009-0006-5512-044X)
- Peng Wang (ORCID: https://orcid.org/0000-0003-0569-9001)
- Hao Zhang (ORCID: https://orcid.org/0000-0002-2049-3485)
- Yuhang Wang (ORCID: https://orcid.org/0009-0008-9915-9121)
- Ruizhi Wang (ORCID: https://orcid.org/0000-0002-2132-7657)
- Junjie Li (ORCID: https://orcid.org/0000-0002-8849-3238)
- Ji‐Jun Chen (ORCID: https://orcid.org/0000-0002-1942-5725)
- Peng Zhao
- Wenjie Cheng
- Rui Zheng (ORCID: https://orcid.org/0000-0002-3151-6128)
- Kuo Shen
Institutions
- Command Hospital Air Force (IN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s13287-025-04722-7
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Key Research and Development Projects of Shaanxi Province