Hypofractionation of Gamma Knife Radiosurgery for Intracranial Meningiomas: A Retrospective Multicenter Study and Systematic Review of Literature
hfGKRS demonstrates durable control and acceptable safety for low-grade intracranial meningiomas. High-grade tumors showed less favorable outcomes comparable with single-session Gamma Knife radiosurgery historical data. Further prospective data are needed to confirm these findings and optimize fractionation strategies.
Authors
- Chandranath Sen (ORCID: https://orcid.org/0000-0003-1603-2958)
- Kenneth E. Bernstein (ORCID: https://orcid.org/0000-0001-8097-3272)
- Douglas Kondziolka (ORCID: https://orcid.org/0000-0001-8925-7344)
- John G. Golfinos (ORCID: https://orcid.org/0000-0003-4221-0180)
- Joshua B. Silverman
- Donato R. Pacione (ORCID: https://orcid.org/0000-0002-0731-442X)
- Elad Mashiach (ORCID: https://orcid.org/0000-0002-6135-6268)
- Derek S. Tsang (ORCID: https://orcid.org/0000-0002-9762-6901)
- Erik P. Sulman (ORCID: https://orcid.org/0000-0003-4933-9120)
- Justin Z. Wang (ORCID: https://orcid.org/0000-0001-8998-7443)
- Suganth Suppiah (ORCID: https://orcid.org/0000-0003-4569-0466)
- Gelareh Mohammed Zadeh (ORCID: https://orcid.org/0000-0002-6637-4502)
- Brandon Santhumayor (ORCID: https://orcid.org/0000-0002-7007-0480)
- Ying Meng (ORCID: https://orcid.org/0000-0003-3180-2404)
- Bernadine R. Donahue
Institutions
- University Health Network (CA)
- Maimonides Medical Center (US)
- University of Toronto (CA)
- Princess Margaret Cancer Centre (CA)
- New York University (US)
Publication Details
- Journal
- Neurosurgery
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1227/neu.0000000000003809
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 0.00