Autophagy Sustained the Activation and Survival of Liver-infiltrating CD8 <sup>+</sup> T Cells in Primary Biliary Cholangitis
Our study indicates autophagy is a critical survival mechanism for intrahepatic T lymphocytes such as CD8<sup>+</sup> T cells, functioning through mROS quenching to maintain cellular viability and sustains liver inflammation. This evidence suggests that modulation of T lymphocyte autophagic processes within the hepatic microenvironment may disrupt immune activation, potentially decelerating PBC progression.
Authors
- Binghui Liu (ORCID: https://orcid.org/0000-0002-0315-3235)
- Bihong Zhu (ORCID: https://orcid.org/0000-0003-2147-1509)
- Jie Li (ORCID: https://orcid.org/0000-0001-5463-3995)
- Jianguo Zhang (ORCID: https://orcid.org/0000-0003-0723-1701)
- Miao He (ORCID: https://orcid.org/0000-0001-7258-3207)
- Qingqing Xia (ORCID: https://orcid.org/0000-0002-9719-0167)
- Zaixing Yang (ORCID: https://orcid.org/0000-0002-7545-642X)
- T. Y. Lin
Institutions
- Wenzhou Medical University (CN)
- Taizhou First People's Hospital (CN)
- Zhejiang Taizhou Hospital (CN)
Publication Details
- Journal
- Immunological Investigations
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1080/08820139.2025.2576138
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00