Modulation of O-GlcNAc cycling influences α-synuclein amplification, degradation, and associated neuroinflammatory pathology
These findings highlight the critical regulatory role of O-GlcNAc modification in α-syn pathology and conformational strain formation, and provide mechanical evidence that enhancing O-GlcNAc modifications alleviates pathological α-syn proteolysis by restoring autophagosome-lysosome flux.
Authors
- Mengni Jiang
- Qiusheng Gu (ORCID: https://orcid.org/0000-0002-3890-3729)
- Ting Zhang (ORCID: https://orcid.org/0000-0001-5882-9661)
- Yongzhen Miao
- Huanhuan Du (ORCID: https://orcid.org/0009-0007-5361-8014)
- Zhuoya Ma
- Chun-Feng Liu (ORCID: https://orcid.org/0000-0001-9318-925X)
- Kangping Xiong
- Hongrui Meng
Institutions
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s13024-025-00904-2
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- National Natural Science Foundation of China
- Soochow University
- Second Affiliated Hospital of Soochow University
- Science and Technology Program of Suzhou