Dynamic multi-omics mechanisms underpinning retinol tolerance: stage-specific reconstruction of skin barrier function and host–microbiome metabolic interactions
Integrated multi-omics correlation analyses further underscored the tightly interconnected regulation of host-microbe energy metabolism, antioxidant defenses, and membrane repair in response to retinol-induced stress. These findings elucidate the temporal interplay between host and microbial processes underpinning retinol tolerance and highlight baseline biomarkers that may facilitate personalized skincare interventions.
Authors
- Qing Zhou (ORCID: https://orcid.org/0000-0002-5432-3652)
- Peng Shu (ORCID: https://orcid.org/0009-0004-6354-8716)
- Wentao Ma (ORCID: https://orcid.org/0000-0002-4747-1489)
- Xiao Liu (ORCID: https://orcid.org/0000-0002-0929-598X)
- Ying Huang (ORCID: https://orcid.org/0000-0002-4627-1661)
- Jingmin Cheng
- Danni Guo
- Minyan Gui
Institutions
- Tsinghua–Berkeley Shenzhen Institute (CN)
- Shenzhen Technology University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fmicb.2025.1668712
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00