Cell-of-Origin Subtype Predicts Response to Polatuzumab Vedotin in Large B-cell Lymphoma

Based on these data, COO classification by the Hans algorithm is a strong predictor of polatuzumab efficacy in LBCL, informing real-world treatment decisions.

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Publication Details

Journal
Clinical Cancer Research
Published
2025-10-27
DOI
https://doi.org/10.1158/1078-0432.ccr-25-2392
Primary Topic
Lymphoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Cell-of-Origin Subtype Predicts Response to Polatuzumab Vedotin in Large B-cell Lymphoma

Hua-Jay Jeffery Cherng, Ryan C. Lynch, Danielle Wallace, Erin Mulvey et al.
Clinical Cancer Research
Lymphoma Diagnosis and Treatment
article

Cell-of-Origin Subtype Predicts Response to Polatuzumab Vedotin in Large B-cell Lymphoma

Hua-Jay Jeffery Cherng, Ryan C. Lynch, Danielle Wallace, Erin Mulvey, Guido D. Pelaez, Marcus P. Watkins, Jihao Zhou, Fei Wan, Muhamad Alhaj Moustafa, David A. Russler‐Germain, Nayef Abdel-Razeq, Pallawi Torka, Joanna Meehan Rhodes, Varun Iyengar, Patrick Gould, Nikita Malakhov, Michelle Fleyshman, Grzegorz S. Nowakowski, Matthew Mei, J. Allen, Reid W. Merryman, Adam Kidwell, Timothy S. Fenske, Ajay Major, Talal Hilal, Samin Houshyar, Narendranath Epperla, Edward R. Scheffer Cliff, Yucai Wang, Kevin Chung, John Sharp, Avyakta Kallam
article en

Abstract

Based on these data, COO classification by the Hans algorithm is a strong predictor of polatuzumab efficacy in LBCL, informing real-world treatment decisions.

Clinical Cancer ResearchVol. 32(1)
Rutgers, The State University of New Jersey (US), Brigham and Women's Hospital (US), City Of Hope National Medical Center (US), Mayo Clinic (US), Memorial Sloan Kettering Cancer Center (US), University of Washington (US), Medical College of Wisconsin (US), Washington University in St. Louis (US), Cornell University (US), Columbia University Irving Medical Center (US), The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US), Peter MacCallum Cancer Centre (AU), Huntsman Cancer Institute (US), Jacksonville College (US), WinnMed (US), University of Rochester Medical Center (US), Fred Hutch Cancer Center (US), Rutgers Sexual and Reproductive Health and Rights (NL), Presbyterian Hospital (US), ShenZhen People’s Hospital (CN), City of Hope (US), Dana-Farber Cancer Institute (US), Mayo Clinic in Arizona (US), Mayo Clinic Hospital (US), Mayo Clinic in Florida (US), Weill Cornell Medicine (US), Rutgers Cancer Institute (US), University of Colorado Anschutz Medical Campus (US), Columbia University (US), University of Colorado Denver (US)
Openalex Percentile: Top 57%
Lymphoma Diagnosis and Treatment
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