Cell-of-Origin Subtype Predicts Response to Polatuzumab Vedotin in Large B-cell Lymphoma
Based on these data, COO classification by the Hans algorithm is a strong predictor of polatuzumab efficacy in LBCL, informing real-world treatment decisions.
Authors
- Hua-Jay Jeffery Cherng (ORCID: https://orcid.org/0000-0002-8266-8447)
- Ryan C. Lynch (ORCID: https://orcid.org/0000-0001-6703-0894)
- Danielle Wallace (ORCID: https://orcid.org/0000-0001-9371-6777)
- Erin Mulvey (ORCID: https://orcid.org/0000-0002-4042-8875)
- Guido D. Pelaez (ORCID: https://orcid.org/0009-0006-8449-8855)
- Marcus P. Watkins (ORCID: https://orcid.org/0000-0002-1224-3478)
- Jihao Zhou (ORCID: https://orcid.org/0000-0002-2684-192X)
- Fei Wan (ORCID: https://orcid.org/0000-0002-8311-5553)
- Muhamad Alhaj Moustafa (ORCID: https://orcid.org/0000-0001-8582-1219)
- David A. Russler‐Germain (ORCID: https://orcid.org/0000-0003-1009-2247)
- Nayef Abdel-Razeq (ORCID: https://orcid.org/0009-0000-2452-2194)
- Pallawi Torka (ORCID: https://orcid.org/0000-0002-1681-5883)
- Joanna Meehan Rhodes (ORCID: https://orcid.org/0000-0002-5068-9040)
- Varun Iyengar (ORCID: https://orcid.org/0000-0002-7712-4605)
- Patrick Gould (ORCID: https://orcid.org/0000-0002-5950-4559)
- Nikita Malakhov (ORCID: https://orcid.org/0000-0002-9954-7406)
- Michelle Fleyshman (ORCID: https://orcid.org/0009-0009-0116-8087)
- Grzegorz S. Nowakowski (ORCID: https://orcid.org/0000-0002-6955-9393)
- Matthew Mei (ORCID: https://orcid.org/0000-0002-1109-6955)
- J. Allen (ORCID: https://orcid.org/0009-0000-8877-4358)
- Reid W. Merryman (ORCID: https://orcid.org/0000-0002-6360-3234)
- Adam Kidwell (ORCID: https://orcid.org/0009-0000-3961-4235)
- Timothy S. Fenske (ORCID: https://orcid.org/0000-0001-7069-0025)
- Ajay Major (ORCID: https://orcid.org/0000-0001-7261-1335)
- Talal Hilal (ORCID: https://orcid.org/0000-0001-8249-4128)
- Samin Houshyar (ORCID: https://orcid.org/0009-0000-8727-436X)
- Narendranath Epperla (ORCID: https://orcid.org/0000-0002-8216-3457)
- Edward R. Scheffer Cliff (ORCID: https://orcid.org/0000-0001-5977-907X)
- Yucai Wang (ORCID: https://orcid.org/0000-0002-1576-8341)
- Kevin Chung (ORCID: https://orcid.org/0000-0002-6189-3688)
- John Sharp (ORCID: https://orcid.org/0000-0001-5765-8549)
- Avyakta Kallam (ORCID: https://orcid.org/0009-0007-9323-4568)
Institutions
- Rutgers, The State University of New Jersey (US)
- Brigham and Women's Hospital (US)
- City Of Hope National Medical Center (US)
- Mayo Clinic (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of Washington (US)
- Medical College of Wisconsin (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- Columbia University Irving Medical Center (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Peter MacCallum Cancer Centre (AU)
- Huntsman Cancer Institute (US)
- Jacksonville College (US)
- WinnMed (US)
- University of Rochester Medical Center (US)
- Fred Hutch Cancer Center (US)
- Rutgers Sexual and Reproductive Health and Rights (NL)
- Presbyterian Hospital (US)
- ShenZhen People’s Hospital (CN)
- City of Hope (US)
- Dana-Farber Cancer Institute (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic Hospital (US)
- Mayo Clinic in Florida (US)
- Weill Cornell Medicine (US)
- Rutgers Cancer Institute (US)
- University of Colorado Anschutz Medical Campus (US)
- Columbia University (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2392
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00