Clinical trial landscape for guided bone regeneration: trend analysis and future perspectives
Research on bone regeneration is undergoing a paradigm shift from the conventional "bone graft + barrier membrane" approach to integrated multicomponent strategies. These advanced strategies combine tunable biodegradable scaffolds, growth factors, and small-molecule drugs to achieve personalized and cost-effective bone defect repair. Future research priorities will focus on optimizing material degradation kinetics and spatial maintenance properties to enhance clinical outcomes.
Authors
- Tianxiang Geng (ORCID: https://orcid.org/0000-0002-9636-3257)
- Xinyue Shen
- Jiani Cao (ORCID: https://orcid.org/0000-0001-8131-1297)
- Zhuojing Luo (ORCID: https://orcid.org/0000-0002-0671-8553)
- Yu Jiang (ORCID: https://orcid.org/0000-0003-4019-8501)
- Hongying Li (ORCID: https://orcid.org/0000-0002-1109-0799)
- Jingwei Xie
- Jin Lou (ORCID: https://orcid.org/0009-0009-3091-8270)
- Yuqing Gui
Institutions
- North Sichuan Medical University (CN)
- Southwest Medical University (CN)
- Yuhuangding Hospital (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
Publication Details
- Journal
- Frontiers in Dental Medicine
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fdmed.2025.1689513
- Primary Topic
- Dental Implant Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China