Spatial self-organization of cancer stem cell niches revealed by live single-cell imaging
Altogether, our results disentangle how phenotypic inheritance and intercellular interactions orchestrate the spatio-temporal self-organization of cancer cell heterogeneity, maintaining a subpopulation of CSCs within niches.
Authors
- Marie Denoulet (ORCID: https://orcid.org/0000-0002-9668-0439)
- Robert‐Alain Toillon (ORCID: https://orcid.org/0000-0001-5483-2118)
- Chann Lagadec (ORCID: https://orcid.org/0000-0002-5182-2069)
- Emeline Fontaine (ORCID: https://orcid.org/0000-0002-6885-8869)
- Flavie Woesteland (ORCID: https://orcid.org/0000-0002-5794-4999)
- Jean Pesez
- Benjamin Pfeuty (ORCID: https://orcid.org/0000-0002-9202-3941)
- Éric Adriaenssens (ORCID: https://orcid.org/0000-0003-3565-5712)
- Anaïs Horochowska (ORCID: https://orcid.org/0000-0002-4687-5799)
- Xuefen Le Bourhis (ORCID: https://orcid.org/0000-0001-6790-6358)
- Mathilde Brulé
- François Anquez (ORCID: https://orcid.org/0000-0002-2071-5527)
- Raoul Torero-Ibad
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers (FR)
- Institut pour la Recherche sur le Cancer de Lille (FR)
- Centre Oscar Lambret (FR)
- Laboratoire de Physique des Lasers, Atomes et Molécules (FR)
- Université d'Angers (FR)
- Nantes Université (FR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s13287-025-04681-z
- Citations
- 1
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.05